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Heparin Induced Thrombocytopenia

Renseignements additionnels

PEP hours: 16
CPS/ART credits: 1.1

Learning Outcomes:

• Describe the mode of action, clinical response and monitoring of unfractionated heparin.
• Contrast and compare low molecular weight heparin with unfractionated heparin.
• Describe briefly the early historical discoveries that have lead to the current knowledge of HIT.
• Explain the nature of the antigen that causes production of HIT antibodies.
• Discuss the steps involved when HIT antibodies cause platelet activation.
• Explain the timeline of HIT.
• Describe the transient nature of HIT antibodies.
• Briefly outline differences in HIT positivitiy between various patient groups.
• Discuss the morbidity and mortality of patients affected with HIT.
• Recognize common nomenclature used to describe HIT in the literature.
• List clinical symptoms of HIT.
• Discuss the variability in platelet ‘alert’ values for suspect HIT cases.
• Briefly discuss the thrombosis risk in a HIT positive patient.
• List other complications that may alert medical staff to a positive HIT patient.
• Briefly describe the methodology used for various HIT assays.
• List the pros and cons of each assay type.
• Explain the difference between HIT and non-immune thrombocytopenia.
• Discuss the possible mechanisms that cause delayed-reaction HIT.
• List alternative anticoagulants suitable for HIT positive patients.
• List treatment options that should avoided in HIT patients.