You will review antigens from definitions to a description of the very properties that make a substance antigenic. Properties such as “foreignness”, molecular size, chemical configuration, manner of introduction, and genetic susceptibility of the host are examined as well as concepts of antigenic determinants, mechanical fit and the use of haptens. A detailed review of several antigens will follow where the nature of bacterial, viral, blood group and other antigens will be discussed. The fate of an antigen with its recognition, phagocytosis, processing to the immune system is also detailed. Finally, a brief mention of T and B cell function is given.

At the completion of this course, the learner will be able to:

• Define antigen, immunogens and immunogenicity
• Tabulate the specificity of autoantibodies seen in the major organ specific autoimmune disease states.
• Describe the experiments of Landsteiner using haptens
• Outline the nature of common antigens experienced by the body
• Describe typical ways an antigen may enter the body
• Describe the nature of frequently used adjuvants
• Explain common examples of cross reactivity seen with certain antibodies
• List examples of the antigens detected in several species of common bacteria
• Outline the principles of the Kauffman and White scheme for serotyping salmonella
• List the nature of antigens and antibodies found with ABO blood groups
• List the nature of antigens and antibodies found with ABO blood groups
• Describe the fate of an injected antigen
• Describe the relationship between antigen, macrophages and lymphocytes
• Outline the concept of T independent vs. T independent antigens
• Briefly describe the basic function of T and B cells in relation to immune surveillance

Who will be your instructor?

John Chapman, FCSMLS, FIMLS, CLSp(H)

• Required Equipment: Computer with at least 500 MB of RAM and internet access to write the exam

Other course details:

• Work at your own pace - you set the schedule. Your studies are supported by the author/instructor, self-assessment exercise and your learning is evaluated by an invigilated quiz (you choose the place and time.
• New! Online computer exam available through E-Learning Society.
• Individuals registered in a self-paced course must complete the course within 12 months of registration. After 12 months the registration will expire. No refund will be provided for expired registrations.
• Course last reviewed/revised: November 2009

Related Categories for this course

• Immunology
• Microbiology
• MODE
• Transfusion Science